Recent advancements in high-level synthesis of the promising clinical drug, prodigiosin.
Appl Microbiol Biotechnol
; 103(4): 1667-1680, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30637495
ABSTRACT
Prodigiosin, a red linear tripyrrole pigment and a member of the prodiginine family, is normally secreted by the human pathogen Serratia marcescens as a secondary metabolite. Studies on prodigiosin have received renewed attention as a result of reported immunosuppressive, antimicrobial and anticancer properties. High-level synthesis of prodigiosin and the bioengineering of strains to synthesise useful prodiginine derivatives have also been a subject of investigation. To exploit the potential use of prodigiosin as a clinical drug targeting bacteria or as a dye for textiles, high-level synthesis of prodigiosin is a prerequisite. This review presents an overview on the biosynthesis of prodigiosin from its natural host Serratia marcescens and through recombinant approaches as well as highlighting the beneficial properties of prodigiosin. We also discuss the prospect of adopting a synthetic biology approach for safe and cost-effective production of prodigiosin in a more industrially compliant surrogate host.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Pigmentos Biológicos
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Prodigiosina
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Serratia marcescens
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Imunossupressores
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Antibacterianos
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Antineoplásicos
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Ano de publicação:
2019
Tipo de documento:
Article