Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives.

Ayman, Marwa; El-Messery, Shahenda M; Habib, Elsayed E; Al-Rashood, Sara T; Almehizia, Abdulrahman A; Alkahtani, Hamad M; Hassan, Ghada S

Ayman, Marwa; El-Messery, Shahenda M; Habib, Elsayed E; Al-Rashood, Sara T; Almehizia, Abdulrahman A; Alkahtani, Hamad M; Hassan, Ghada S.

Afiliação

Ayman M; Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
El-Messery SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt. Electronic address: selmessery@gmail.com.
Habib EE; Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Almadinah Almunawwarah 344, Saudi Arabia; Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Almehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Hassan GS; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt. Electronic address: ghadasameh@mans.edu.eg.

Bioorg Chem ; 85: 282-292, 2019 04.

Article em En | MEDLINE | ID: mdl-30641322

Assuntos

Antibacterianos/farmacologia; Chalconas/farmacologia; DNA/metabolismo; Substâncias Intercalantes/farmacologia; Tiocarbamatos/farmacologia; Antibacterianos/síntese química; Antibacterianos/metabolismo; Domínio Catalítico; Chalconas/síntese química; Chalconas/metabolismo; Colistina/farmacologia; Doxorrubicina/farmacologia; Etanolaminofosfotransferase/química; Etanolaminofosfotransferase/metabolismo; Substâncias Intercalantes/síntese química; Substâncias Intercalantes/metabolismo; Klebsiella pneumoniae/efeitos dos fármacos; Testes de Sensibilidade Microbiana; Simulação de Acoplamento Molecular; Estrutura Molecular; Neisseria meningitidis/enzimologia; Pseudomonas aeruginosa/efeitos dos fármacos; Relação Estrutura-Atividade; Tiocarbamatos/síntese química; Tiocarbamatos/metabolismo

Palavras-chave

Bacterial resistance; Dithiocarbamate chalcones; Molecular docking studies; Synthesis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Tiocarbamatos / DNA / Chalconas / Substâncias Intercalantes / Antibacterianos Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article

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