Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.
Chemosphere
; 221: 471-478, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-30654261
ABSTRACT
The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BPA Glucuronide. Fourteen placentas at term were perfused in an open dual circuit with deuterated BPS (1 and 5⯵M) and non-labelled BPSG (2.5⯵M) and a freely diffusing marker antipyrine (800â¯ng/ml) in the presence of albumin (25â¯mg/ml). In a second experiment, the potential role of P-glycoprotein in the active efflux of BPS across the placental barrier was studied using the well-established P-glycoprotein inhibitor, PSC833 (2 and 4⯵M). Placental transfer of BPS was much lower than that of BPA in both directions. The placental clearance index of BPS in the materno-fetal direction was three times lower than in the opposite direction, strongly suggesting some active efflux transport. However, our results show that P-glycoprotein is not involved in limiting the materno-fetal transfer of BPS. Placental transfer of BPSG in the fetal compartment was almost non-existent indicating that, in the fetal compartment, BPSG originates mainly from feto-placental metabolism. The feto-maternal clearance index for BPSG was 20-fold higher than the materno-fetal index. We conclude that the blood-placental barrier is much more efficient in limiting fetal exposure to BPS than to BPA, indicating that the placenta has a crucial role in protecting the human fetus from BPS exposure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
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Placenta
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Sulfonas
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Compostos Benzidrílicos
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Feto
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Troca Materno-Fetal
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
2019
Tipo de documento:
Article