Synthesis and anti-HCV activity of ß-d-2'-deoxy-2'-&#945;-chloro-2'-ß-fluoro and ß-d-2'-deoxy-2'-&#945;-bromo-2'-ß-fluoro nucleosides and their phosphoramidate prodrugs.

Ovadia, Reuben; Khalil, Ahmed; Li, Hao; De Schutter, Coralie; Mengshetti, Seema; Zhou, Shaoman; Bassit, Leda; Coats, Steven J; Amblard, Franck; Schinazi, Raymond F

Synthesis and anti-HCV activity of ß-d-2'-deoxy-2'-α-chloro-2'-ß-fluoro and ß-d-2'-deoxy-2'-α-bromo-2'-ß-fluoro nucleosides and their phosphoramidate prodrugs.

Ovadia, Reuben; Khalil, Ahmed; Li, Hao; De Schutter, Coralie; Mengshetti, Seema; Zhou, Shaoman; Bassit, Leda; Coats, Steven J; Amblard, Franck; Schinazi, Raymond F.

Afiliação

Ovadia R; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Khalil A; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Li H; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
De Schutter C; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Mengshetti S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Zhou S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Bassit L; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Coats SJ; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: rschina@emory.edu.

Bioorg Med Chem ; 27(4): 664-676, 2019 02 15.

Article em En | MEDLINE | ID: mdl-30655167

Assuntos

Antivirais/farmacologia; Desoxirribonucleosídeos/farmacologia; Hepacivirus/efeitos dos fármacos; Pró-Fármacos/farmacologia; Animais; Antivirais/síntese química; Antivirais/química; Linhagem Celular Tumoral; Chlorocebus aethiops; Desoxirribonucleosídeos/síntese química; Desoxirribonucleosídeos/química; Humanos; Pró-Fármacos/síntese química; Pró-Fármacos/química; Estereoisomerismo; Células Vero

Palavras-chave

Antivirals; Fluorination; Nucleosides; Prodrugs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pró-Fármacos / Hepacivirus / Desoxirribonucleosídeos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2019 Tipo de documento: Article

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