Blood reference intervals for rabbits (Oryctolagus cuniculus) from routine diagnostic samples.

ABSTRACT

OBJECTIVE: The goal of this study was to establish reference intervals for blood parameters in rabbits based on data from routine diagnostic samples. MATERIALS AND METHODS: Data sets from 1679-2039 values for clinical chemistry and 937-1559 values for hematological parameters were evaluated using the statistical program Reference Limit Estimator 20151017. RESULTS: The following reference intervals were calculated for hematology erythrocytes 4.37-7.43 × 1012 cells/l; hematocrit 0.28-0.48 l/l; hemoglobin 89.63-153.82 g/l; leucocytes 2.71-12.23 × 109 cells/l; neutrophils 0.87-7.82 × 109 cells/l; lymphocytes 0.36-6.58 × 109 cells/l; monocytes 0.08-1.71 × 109 cells/l; eosi nophils 0.07-0.19 × 109 cells/l; basophils 0.06-1.1 × 109 cells/l; thrombocytes 225.45-905.3 × 109 cells/l. Calculated intervals for clinical chemistries were alkaline phosphatase 9.05-94.68 U/l; aspartataminotransferase 3.75-32.44 U/l; creatine kinase 1.63-559.53 U/l; γ-glutamyltransferase 2.5-14.46 U/l; glutamatdehydrogenase 0.68-14.78 U/l; fructosamin 248.08-501.43 µmol/l; bile acid 0.76-19.63 µmol/l; total protein 48.66-73.64 g/l; urea 2.63-10.28 mmol/l; creatinine 51.38-154.35 µmol/l; calcium 3.02-4.3 mmol/l; magnesium 0.66-1.51 mmol/l; phosphorus 0.54-2.18 mmol/l; sodium 132.61- 154.0 mmol/l and potassium 3.52-6.04 mmol/l. CONCLUSION AND CLINICAL RELEVANCE The calculation of intervals based on a large number of routine diagnostic samples allows the establishment of labora tory specific reference intervals without the use of experimental animals.