Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity.
Molecules
; 24(2)2019 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-30658485
ABSTRACT
Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis Aâ»E (1â»5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1â»5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 µM compared to Cisplatin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Cucurbitaceae
/
Tubérculos
/
Glicosídeos
Limite:
Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2019
Tipo de documento:
Article