Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.

Zhao, Xian-En; He, Yongrui; Zhu, Shuyun; Xu, Yanqiu; You, Jinmao; Bai, Yu; Liu, Huwei

Zhao, Xian-En; He, Yongrui; Zhu, Shuyun; Xu, Yanqiu; You, Jinmao; Bai, Yu; Liu, Huwei.

Afiliação

Zhao XE; Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China. Electronic address: xianenzhao@163.com.
He Y; Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.
Zhu S; Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.
Xu Y; Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.
You J; Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.
Bai Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Liu H; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. Electronic address: hwliu@pku.e

Anal Chim Acta ; 1051: 73-81, 2019 Mar 21.

Article em En | MEDLINE | ID: mdl-30661621

Assuntos

Álcoois Benzílicos/uso terapêutico; Encéfalo/metabolismo; Depressão/metabolismo; Glucosídeos/uso terapêutico; Neurotransmissores/isolamento & purificação; Neurotransmissores/metabolismo; Acidente Vascular Cerebral/tratamento farmacológico; Animais; Álcoois Benzílicos/administração & dosagem; Álcoois Benzílicos/sangue; Álcoois Benzílicos/farmacologia; Encéfalo/efeitos dos fármacos; Cromatografia Líquida de Alta Pressão; Glucosídeos/administração & dosagem; Glucosídeos/sangue; Glucosídeos/farmacologia; Marcação por Isótopo; Limite de Detecção; Imãs/química; Neurotransmissores/química; Ratos; Extração em Fase Sólida; Acidente Vascular Cerebral/complicações; Acidente Vascular Cerebral/psicologia; Espectrometria de Massas em Tandem; Temperatura; Fatores de Tempo

Palavras-chave

In vivo microdialysis; Magnetic dispersive solid phase extraction; Neurotransmitters; Post-stroke depression; Stable isotope labeling derivatization; Triple quadrupole mass spectrometry

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Benzílicos / Encéfalo / Neurotransmissores / Acidente Vascular Cerebral / Depressão / Glucosídeos Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Anal Chim Acta Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google