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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.
Ericksen, Russell E; Lim, Siew Lan; McDonnell, Eoin; Shuen, Wai Ho; Vadiveloo, Maya; White, Phillip J; Ding, Zhaobing; Kwok, Royston; Lee, Philip; Radda, George K; Toh, Han Chong; Hirschey, Matthew D; Han, Weiping.
Afiliação
  • Ericksen RE; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • Lim SL; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • McDonnell E; Duke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.
  • Shuen WH; Division of Medical Oncology, National Cancer Center Singapore, 11 Hospital Drive, 169610 Singapore, Singapore.
  • Vadiveloo M; Department of Nutrition and Food Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA.
  • White PJ; Duke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.
  • Ding Z; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • Kwok R; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • Lee P; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • Radda GK; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore.
  • Toh HC; Division of Medical Oncology, National Cancer Center Singapore, 11 Hospital Drive, 169610 Singapore, Singapore.
  • Hirschey MD; Duke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.
  • Han W; Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, 11 Biopolis Way, 138667 Singapore, Singapore. Electronic address: weiping_han@sbic.a-star.edu.sg.
Cell Metab ; 29(5): 1151-1165.e6, 2019 05 07.
Article em En | MEDLINE | ID: mdl-30661928
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Carcinoma Hepatocelular / Progressão da Doença / Carcinogênese / Alvo Mecanístico do Complexo 1 de Rapamicina / Aminoácidos de Cadeia Ramificada / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação para Baixo / Carcinoma Hepatocelular / Progressão da Doença / Carcinogênese / Alvo Mecanístico do Complexo 1 de Rapamicina / Aminoácidos de Cadeia Ramificada / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Ano de publicação: 2019 Tipo de documento: Article