Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes.
Lab Anim Res
; 34(4): 147-159, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30671100
ABSTRACT
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre-loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Lab Anim Res
Ano de publicação:
2018
Tipo de documento:
Article