Brain Mineralocorticoid Receptors and Resilience to Stress.
Vitam Horm
; 109: 341-359, 2019.
Article
em En
| MEDLINE
| ID: mdl-30678862
ABSTRACT
Exposure to stressful experiences triggers the release of-among others-glucocorticoids from the adrenal glands. These hormones, cortisol and corticosterone in humans and rodents respectively, activate mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that regulate neuronal activity and behavioral adaptation to stressful experiences. This review discusses molecular properties of MRs, the role of MRs in regulating neuronal function and behavior and, ultimately, evidence that enhanced MR function may confer resilience to stressful experiences.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Estresse Fisiológico
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Encéfalo
/
Receptores de Mineralocorticoides
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Sistema Hipotálamo-Hipofisário
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Vitam Horm
Ano de publicação:
2019
Tipo de documento:
Article