Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan.
Environ Health Prev Med
; 24(1): 8, 2019 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-30684957
ABSTRACT
BACKGROUND:
In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan.METHODS:
Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß2-microglobulin and blood and urinary cadmium levels were measured.RESULTS:
The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß2-microglobulin level higher than 10,000 µg/g cr. and a blood cadmium level higher than 6 µg/L or urinary cadmium level higher than 10 µg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy.CONCLUSIONS:
This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. REGISTRATION NUMBER No. 6, date of registration 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration 26 December, 2013 (Akita University).Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Cádmio
/
Intoxicação por Cádmio
/
Poluentes Ambientais
/
Nefropatias
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environ Health Prev Med
Ano de publicação:
2019
Tipo de documento:
Article