Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors.

Fu, Dong-Jun; Li, Ping; Wu, Bo-Wen; Cui, Xin-Xin; Zhao, Cheng-Bin; Zhang, Sai-Yang

Fu, Dong-Jun; Li, Ping; Wu, Bo-Wen; Cui, Xin-Xin; Zhao, Cheng-Bin; Zhang, Sai-Yang.

Afiliação

Fu DJ; School of Basic Medical Science, Zhengzhou University, Zhengzhou, 450001, China; School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China.
Li P; School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China.
Wu BW; School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China.
Cui XX; School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China.
Zhao CB; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhang SY; School of Basic Medical Science, Zhengzhou University, Zhengzhou, 450001, China; The Academy of Medical Science, Zhengzhou University, Zhengzhou, 450001, China; Henan Institutes of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, China; School of Pharmaceutical Sciences & Collaborat

Eur J Med Chem ; 165: 309-322, 2019 Mar 01.

Article em En | MEDLINE | ID: mdl-30690300

Assuntos

Antineoplásicos/síntese química; Triazóis/química; Tubulina (Proteína)/efeitos dos fármacos; Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Colchicina/metabolismo; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Polimerização/efeitos dos fármacos; Relação Estrutura-Atividade; Triazóis/síntese química; Triazóis/uso terapêutico; Tubulina (Proteína)/metabolismo

Palavras-chave

Apoptosis; Cell cycle; Colchicine site tubulin inhibitor; Coumarin; Trimethoxyphenyl-1,2,3-triazole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Tubulina (Proteína) / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article

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