Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.

Fasinu, Pius S; Nanayakkara, N P Dhammika; Wang, Yan-Hong; Chaurasiya, Narayan D; Herath, H M Bandara; McChesney, James D; Avula, Bharathi; Khan, Ikhlas; Tekwani, Babu L; Walker, Larry A

Fasinu, Pius S; Nanayakkara, N P Dhammika; Wang, Yan-Hong; Chaurasiya, Narayan D; Herath, H M Bandara; McChesney, James D; Avula, Bharathi; Khan, Ikhlas; Tekwani, Babu L; Walker, Larry A.

Afiliação

Fasinu PS; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA. fasinu@campbell.edu.
Nanayakkara NPD; Department of Pharmaceutical Sciences, Campbell University, Buies Creek, NC, 27501, USA. fasinu@campbell.edu.
Wang YH; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Chaurasiya ND; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Herath HMB; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
McChesney JD; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Avula B; Ironstone Separations, Inc., Etta, MS, 38627, USA.
Khan I; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Tekwani BL; The National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Walker LA; Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.

Malar J ; 18(1): 30, 2019 Jan 30.

Article em En | MEDLINE | ID: mdl-30700282

Assuntos

Antimaláricos/metabolismo; Eritrócitos/metabolismo; Primaquina/metabolismo; Quinonas/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Biotransformação; Cromatografia Líquida de Alta Pressão; Humanos; Técnicas In Vitro; Espectrometria de Massas em Tandem

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Primaquina / Quinonas / Espécies Reativas de Oxigênio / Eritrócitos / Antimaláricos Limite: Humans Idioma: En Revista: Malar J Ano de publicação: 2019 Tipo de documento: Article

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