A Novel Phospholipase A2 Isolated from Palythoa caribaeorum Possesses Neurotoxic Activity.
Toxins (Basel)
; 11(2)2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30717279
ABSTRACT
Zoanthids of the genus Palythoa are distributed worldwide in shallow waters around coral reefs. Like all cnidarians, they possess nematocysts that contain a large diversity of toxins that paralyze their prey. This work was aimed at isolating and functionally characterizing a cnidarian neurotoxic phospholipase named A2-PLTX-Pcb1a for the first time. This phospholipase was isolated from the venomous extract of the zoanthid Palythoa caribaeorum. This enzyme, which is Ca2+-dependent, is a 149 amino acid residue protein. The analysis of the A2-PLTX-Pcb1a sequence showed neurotoxic domain similitude with other neurotoxic sPLA2´s, but a different catalytic histidine domain. This is remarkable, since A2-PLTX-Pcb1a displays properties like those of other known PLA2 enzymes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Neurotóxicas
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Antozoários
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Fosfolipases A2
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Córtex Motor
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Neurotoxinas
Limite:
Animals
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2019
Tipo de documento:
Article