Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat.
Nat Prod Res
; 34(23): 3328-3334, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-30720345
ABSTRACT
Two new lignans (1-2), along with five known compounds (3-7) with different structures were isolated from leaves and twigs of Cleistanthus concinnus Croizat. The new lignans were elucidated as (7'R,8'S)-3,3',5'-trimethoxy-4,4'-dihydroxy-7-en-7',9- epoxy-8,8'-lignan (1) and (7'R,8'S)-3,3'-dimethoxy-4,4'-dihydroxy-7-en-7',9-epoxy-8, 8'-lignan (2) by comprehensive spectroscopic analysis including 1D and 2D NMR as well as HREIMS and comparing their NMR data with known compounds in the literature. Among these isolated compounds, compound 1, 2, 3, and 6 were tested for anti- inflammatory effects by inhibiting NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Compound 1, 2, and 6 exhibit NO inhibitory activity.[Formula see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Euphorbiaceae
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2020
Tipo de documento:
Article