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Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivry gland epithelial cells.
Lee, Jun-Han; Jeong, Joseph H; Kim, Tae-Hwan; Kim, So-Yeon; Kim, Kyung-Eun; Seong, Je Kyung; Lee, Sang Hyuk.
Afiliação
  • Lee JH; Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Jeong JH; Department of Developmental Biology and Genomics, College of Veterinary Medicine, Korea Mouse Phenotyping Center, Seoul National University, Seoul, Korea.
  • Kim TH; Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kim SY; Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kim KE; Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Seong JK; Department of Developmental Biology and Genomics, College of Veterinary Medicine, Korea Mouse Phenotyping Center, Seoul National University, Seoul, Korea.
  • Lee SH; Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Head Neck ; 41(4): 924-929, 2019 04.
Article em En | MEDLINE | ID: mdl-30723988
BACKGROUND: Salivary gland neoplasms are relatively rare and comprise only 1%-4% of all human neoplasms. Salivary gland neoplasms also show an extremely wide range of morphological diversity. Currently, the genetic alterations and corresponding molecular mechanisms underlying salivary gland neoplasms development remain largely unknown. METHOD: We generated an inducible Tet-MAP3K8::MMTV-rTA mouse model by crossing the MAP3K8 transgenic mice with MMTR-rTA transgenic mice to express MAP3K8 in the salivary gland. RESULTS: MAP3K8 overexpression in the murine salivary glands of Tet-MAP3K8::MMTR-rTA transgenic mice induces tumorigenesis. Pathological investigations reveal partial fibrosis and adenosis of salivary glands, and foci of atypical squamoid cellular proliferation, which represent invasive squamous cell carcinoma (SCC). CONCLUSION: MAP3K8 overexpression is associated with SCC development in murine salivary glands. It provides an in vivo framework for the understanding of molecular mechanisms underlying SCC development in the salivary glands and also for the development of a future therapeutic strategy targeting this tumor type.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma de Células Escamosas / Regulação para Cima / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas / MAP Quinase Quinase Quinases Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Animals / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Head Neck Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma de Células Escamosas / Regulação para Cima / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas / MAP Quinase Quinase Quinases Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Animals / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Head Neck Ano de publicação: 2019 Tipo de documento: Article