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Genome Engineering Approaches to Improve Nosokomycin A Production by Streptomyces ghanaensis B38.3.

Kuzhyk, Yuriy; Lopatniuk, Maria; Luzhetskyy, Andriy; Fedorenko, Victor; Ostash, Bohdan.
Indian J Microbiol; 59(1): 109-111, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30728639
Here we describe our efforts to improve the levels of phosphoglycolipid antibiotic nosokomycin A production by Streptomyces ghanaensis ATCC14672 via genome engineering approaches. Introduction of two extra copies of leucyl tRNA (UUA) gene bldA and one copy of moenomycin biosynthesis gene cluster led, on average, to threefold increase in nosokomycin A titers (up to 1.5 mg/L). Our results validate genome engineering approach as a viable strategy to improve moenomycin production.
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