Type I interferon protects neurons from prions in in vivo models.

Ishibashi, Daisuke; Homma, Takujiro; Nakagaki, Takehiro; Fuse, Takayuki; Sano, Kazunori; Satoh, Katsuya; Mori, Tsuyoshi; Atarashi, Ryuichiro; Nishida, Noriyuki

Ishibashi, Daisuke; Homma, Takujiro; Nakagaki, Takehiro; Fuse, Takayuki; Sano, Kazunori; Satoh, Katsuya; Mori, Tsuyoshi; Atarashi, Ryuichiro; Nishida, Noriyuki.

Afiliação

Ishibashi D; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Homma T; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.
Nakagaki T; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Fuse T; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Sano K; Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Satoh K; Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mori T; Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Atarashi R; Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Nishida N; Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Brain ; 142(4): 1035-1050, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30753318

Assuntos

Interferon Tipo I/fisiologia; Doenças Priônicas/patologia; Príons/metabolismo; Animais; Encéfalo/patologia; Humanos; Imunidade Inata; Fator Regulador 3 de Interferon/metabolismo; Interferon Tipo I/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Neurônios/metabolismo; Doenças Priônicas/imunologia; Doenças Priônicas/metabolismo; Proteínas Priônicas/metabolismo; Príons/patogenicidade; Receptor de Interferon alfa e beta/metabolismo; Transdução de Sinais

Palavras-chave

innate immune system; prion infection; type I interferon (I-IFN)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Interferon Tipo I / Doenças Priônicas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Brain Ano de publicação: 2019 Tipo de documento: Article

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