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Parallel adaptation of rabbit populations to myxoma virus.
Alves, Joel M; Carneiro, Miguel; Cheng, Jade Y; Lemos de Matos, Ana; Rahman, Masmudur M; Loog, Liisa; Campos, Paula F; Wales, Nathan; Eriksson, Anders; Manica, Andrea; Strive, Tanja; Graham, Stephen C; Afonso, Sandra; Bell, Diana J; Belmont, Laura; Day, Jonathan P; Fuller, Susan J; Marchandeau, Stéphane; Palmer, William J; Queney, Guillaume; Surridge, Alison K; Vieira, Filipe G; McFadden, Grant; Nielsen, Rasmus; Gilbert, M Thomas P; Esteves, Pedro J; Ferrand, Nuno; Jiggins, Francis M.
Afiliação
  • Alves JM; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. joel.alves@arch.ox.ac.uk miguel.carneiro@cibio.up.pt fmj1001@cam.ac.uk.
  • Carneiro M; CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.
  • Cheng JY; Palaeogenomics and Bio-Archaeology Research Network Research Laboratory for Archaeology and History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK.
  • Lemos de Matos A; CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal. joel.alves@arch.ox.ac.uk miguel.carneiro@cibio.up.pt fmj1001@cam.ac.uk.
  • Rahman MM; Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.
  • Loog L; Departments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Campos PF; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.
  • Wales N; The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
  • Eriksson A; The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
  • Manica A; Palaeogenomics and Bio-Archaeology Research Network Research Laboratory for Archaeology and History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK.
  • Strive T; Manchester Institute of Biotechnology, School of Earth and Environmental Sciences, University of Manchester, Manchester M1 7DN, UK.
  • Graham SC; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.
  • Afonso S; CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
  • Bell DJ; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.
  • Belmont L; Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, CA 94720, USA.
  • Day JP; Department of Archaeology, University of York, King's Manor, York YO1 7EP, UK.
  • Fuller SJ; Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.
  • Marchandeau S; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
  • Palmer WJ; Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.
  • Queney G; Centre for Invasive Species Solutions, University of Canberra, Bruce, ACT 2601, Australia.
  • Surridge AK; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
  • Vieira FG; CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.
  • McFadden G; Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
  • Nielsen R; The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
  • Gilbert MTP; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Esteves PJ; School of Earth, Environmental and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia.
  • Ferrand N; Office National de la Chasse et de la Faune Sauvage, Nantes, France.
  • Jiggins FM; The Genome Center and Department of Plant Sciences, University of California, Davis, CA 95616, USA.
Science ; 363(6433): 1319-1326, 2019 03 22.
Article em En | MEDLINE | ID: mdl-30765607
ABSTRACT
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coelhos / Adaptação Biológica / Imunidade Inata / Myxoma virus / Mixomatose Infecciosa Limite: Animals País/Região como assunto: Europa / Oceania Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coelhos / Adaptação Biológica / Imunidade Inata / Myxoma virus / Mixomatose Infecciosa Limite: Animals País/Região como assunto: Europa / Oceania Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article