In vitro anti-platelet aggregation effects of fourteen fruits and vegetables.
Pak J Pharm Sci
; 32(1): 185-195, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30772808
ABSTRACT
In the present study, the anti-platelet aggregation activity of 14 vegetables and fruits was tested in vitro. The aqueous, 90% ethanol and ethyl acetate extracts, as well as concentrated juices of 14 foods (fruits and vegetables) were prepared, and the anti-platelet aggregation activity of those extracts was analyzed on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate (ADP), bovine thrombin (THR) and arachidonic acid (AA) as aggregation inducers, respectively. Aspirin (ASP) was used as the positive control. A number of the tested foods had inhibitory effects in concentration-dependent manner on platelet aggregations induced by various agonists. Especially, some foods such as lemon, leek, garlic, scallion, ginger, tomato and grapefruit showed good anti-platelet aggregation effect similar or higher than that of positive control group i.e. aspirin (ASP). The results of present study provide scientific reference for reasonable selection of daily dietary with supplementary curative effects or prevention of cardiovascular diseases (CVD).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Verduras
/
Inibidores da Agregação Plaquetária
/
Extratos Vegetais
/
Agregação Plaquetária
/
Sucos de Frutas e Vegetais
/
Frutas
Limite:
Animals
Idioma:
En
Revista:
Pak J Pharm Sci
Ano de publicação:
2019
Tipo de documento:
Article