Mutagenesis of &#945;-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors.

Turner, Matthew W; Marquart, Leanna A; Phillips, Paul D; McDougal, Owen M

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors.

Turner, Matthew W; Marquart, Leanna A; Phillips, Paul D; McDougal, Owen M.

Afiliação

Turner MW; Biomolecular Sciences Graduate Programs, Boise State University; Boise, ID 83725, USA. matthewturner1@u.boisestate.edu.
Marquart LA; Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. leannabrown@boisestate.edu.
Phillips PD; Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. paul.dan.phillips@gmail.com.
McDougal OM; Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. owenmcdougal@boisestate.edu.

Toxins (Basel) ; 11(2)2019 02 13.

Article em En | MEDLINE | ID: mdl-30781866

Assuntos

Conotoxinas/genética; Conotoxinas/metabolismo; Receptores Nicotínicos/química; Receptores Nicotínicos/metabolismo; Animais; Humanos; Mutagênese; Mutação; Conformação Proteica; Relação Estrutura-Atividade

Palavras-chave

acetylcholine binding protein (AChBP); genetic algorithm managed peptide mutant screening (GAMPMS); molecular dynamics (MD); mutational analysis; nicotinic acetylcholine receptors (nAChRs); positional scanning synthetic combinatorial libraries (PS-SCL); protein surface topography (PST); solid phase peptide synthesis (SPPS); α-conotoxins (α-CTxs)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Conotoxinas Limite: Animals / Humans Idioma: En Revista: Toxins (Basel) Ano de publicação: 2019 Tipo de documento: Article

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