Emerging treatments for short bowel syndrome in adult patients.
Expert Rev Gastroenterol Hepatol
; 13(3): 241-246, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30791759
ABSTRACT
INTRODUCTION:
Short bowel syndrome (SBS) is the major cause of chronic intestinal failure (IF), defined as 'the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth'. Areas covered Spontaneous intestinal adaptation, including increased hormonal secretion, development of hyperphagia and gut microbiota dysbiosis, occurs 2 years after resection, improving intestinal absorption and decreasing PN dependency. Hormonal treatments, promoting intestinal hyperadaptation, have been proposed in patients with SBS with chronic IF. Clinical studies showed teduglutide to increase urine production and reduce the need for parenteral support volume in these patients. According to the latest ESPEN Guidelines, if a growth factor treatment is considered, the GPL2 analog, teduglutide, should be the first-choice treatment. Expert opinion These therapies underline the importance of patient monitoring at home and the complexity for HPN adaptation. A multidisciplinary approach should be a gold standard.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Intestino Curto
/
Fármacos Gastrointestinais
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Nutrição Parenteral no Domicílio
/
Intestinos
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Gastroenterol Hepatol
Ano de publicação:
2019
Tipo de documento:
Article