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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.
Jin, Shuai; Zong, Yuan; Gao, Qiang; Zhu, Zixu; Wang, Yanpeng; Qin, Peng; Liang, Chengzhi; Wang, Daowen; Qiu, Jin-Long; Zhang, Feng; Gao, Caixia.
Afiliação
  • Jin S; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  • Zong Y; University of Chinese Academy of Sciences, Beijing 100864, China.
  • Gao Q; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  • Zhu Z; University of Chinese Academy of Sciences, Beijing 100864, China.
  • Wang Y; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  • Qin P; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  • Liang C; University of Chinese Academy of Sciences, Beijing 100864, China.
  • Wang D; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  • Qiu JL; Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China.
  • Zhang F; University of Chinese Academy of Sciences, Beijing 100864, China.
  • Gao C; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Science ; 364(6437): 292-295, 2019 04 19.
Article em En | MEDLINE | ID: mdl-30819931
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oryza / Análise Mutacional de DNA / Citosina / Edição de Genes / Sequenciamento Completo do Genoma Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oryza / Análise Mutacional de DNA / Citosina / Edição de Genes / Sequenciamento Completo do Genoma Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article