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Circulating HO-1 levels are not associated with plasma sFLT-1 and GTn HMOX1 polymorphism in preeclampsia.
Sandrim, Valeria; Coeli-Lacchini, Fernanda Borchers; Tanus-Santos, Jose Eduardo; Lacchini, Riccardo; Cavalli, Ricardo Carvalho.
Afiliação
  • Sandrim V; a Department of Pharmacology , Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
  • Coeli-Lacchini FB; b Departments of Internal Medicine , Ribeirao Preto College of Nursing, University of Sao Paulo , Ribeirao Preto , Brazil.
  • Tanus-Santos JE; c Departments of Pharmacology , Ribeirao Preto College of Nursing, University of Sao Paulo , Ribeirao Preto , Brazil.
  • Lacchini R; d Department of Psychiatric Nursing and Human Sciences , Ribeirao Preto College of Nursing, University of Sao Paulo , Ribeirao Preto , Brazil.
  • Cavalli RC; e Departments of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto , Ribeirao Preto College of Nursing, University of Sao Paulo , Ribeirao Preto , Brazil.
Hypertens Pregnancy ; 38(2): 73-77, 2019 May.
Article em En | MEDLINE | ID: mdl-30835584
ABSTRACT

OBJECTIVES:

We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene.

METHODS:

HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis.

RESULTS:

We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed.

CONCLUSION:

The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GTn polymorphism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Heme Oxigenase-1 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hypertens Pregnancy Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Heme Oxigenase-1 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hypertens Pregnancy Ano de publicação: 2019 Tipo de documento: Article