Circulating HO-1 levels are not associated with plasma sFLT-1 and GTn HMOX1 polymorphism in preeclampsia.
Hypertens Pregnancy
; 38(2): 73-77, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30835584
ABSTRACT
OBJECTIVES:
We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene.METHODS:
HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis.RESULTS:
We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed.CONCLUSION:
The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GTn polymorphism.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Heme Oxigenase-1
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hypertens Pregnancy
Ano de publicação:
2019
Tipo de documento:
Article