Structural requirement of tunicamycin V for MraY inhibition.
Bioorg Med Chem
; 27(8): 1714-1719, 2019 04 15.
Article
em En
| MEDLINE
| ID: mdl-30850266
ABSTRACT
Elucidating a structure-activity relationship study by evaluating a series of truncated analogues is a simple but important and effective tactic in medicinal chemistry based on natural products with a large and complex chemical structure. In this study, a series of truncated analogues of tunicamycin V were designed and synthesized and their MraY inhibitory activity was investigated in order to gain insight into the effect of these moieties on MraY inhibition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Transferases
/
Tunicamicina
/
Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2019
Tipo de documento:
Article