Multi-Omics Strategies Uncover Host-Pathogen Interactions.
ACS Infect Dis
; 5(4): 493-505, 2019 04 12.
Article
em En
| MEDLINE
| ID: mdl-30857388
ABSTRACT
With the success of the Human Genome Project, large-scale systemic projects became a reality that enabled rapid development of the systems biology field. Systems biology approaches to host-pathogen interactions have been instrumental in the discovery of some specifics of Gram-negative bacterial recognition, host signal transduction, and immune tolerance. However, further research, particularly using multi-omics approaches, is essential to untangle the genetic, immunologic, (post)transcriptional, (post)translational, and metabolic mechanisms underlying progression from infection to clearance of microbes. The key to understanding host-pathogen interactions lies in acquiring, analyzing, and modeling multimodal data obtained through integrative multi-omics experiments. In this article, we will discuss how multi-omics analyses are adding to our understanding of the molecular basis of host-pathogen interactions and systemic maladaptive immune response of the host to microbes and microbial products.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Negativas
/
Biologia de Sistemas
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Interações Hospedeiro-Patógeno
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Bactérias Gram-Negativas
Limite:
Animals
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Humans
Idioma:
En
Revista:
ACS Infect Dis
Ano de publicação:
2019
Tipo de documento:
Article