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A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.
Lopez-Tapia, Francisco; Lou, Yan; Brotherton-Pleiss, Christine; Kuglstatter, Andreas; So, Sung-Sau; Kondru, Rama.
Afiliação
  • Lopez-Tapia F; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States. Electronic address: ftapia@cc.hawaii.edu.
  • Lou Y; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Brotherton-Pleiss C; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Kuglstatter A; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • So SS; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Kondru R; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
Bioorg Med Chem Lett ; 29(9): 1074-1078, 2019 05 01.
Article em En | MEDLINE | ID: mdl-30857747
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Tirosina Quinase da Agamaglobulinemia Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores de Proteínas Quinases / Tirosina Quinase da Agamaglobulinemia Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2019 Tipo de documento: Article