Vitamin D deficiency as a risk factor for PFAPA syndrome.
Int J Pediatr Otorhinolaryngol
; 121: 55-57, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30870794
ABSTRACT
OBJECTIVE:
The periodic fever, aphthous stomatitis, pharangytis and cervical adenitis (PFAPA) syndrome, is an idiopathic chronic disease of non-hereditary origin, primarily affecting pre-school children and is the most common periodic fever disorder in children. Rapid response to corticosteroid treatment suggest an immune dysregulation. Recently, emerging evidence suggest that vitamin D plays an important role in immunity regulation. The aim of our study was to assess the vitamin D levels in children with PFAPA syndrome.METHODS:
This study was conducted prospectively. We have consecutively evaluated 50 patients after having excluded other causes of recurrent fever between May 2017 and May 2018 in addition to age-matched 50 patients as control group. All patients has complete physical examination and laboratory tests. Laboratory tests included complete blood count, C-reactive protein (CRP), and vitamin D levels. Serum 25 (OH) vitamin D levels were measured in all patients twice yearly.RESULTS:
Vitamin D levels was 18⯱â¯10â¯ng/ml in the patient group and 35⯱â¯13â¯ng/ml in the control group. There was statistically significant difference between the groups (pâ¯<â¯0.001). 38 patients from the PFAPA group and 20 patients from the control group had low vitamin D levels. Multivariate logistic regression analysis showed that CRP (odd ratio (OR)â¯=â¯2.7, 95% confidence interval (CI)â¯=â¯2.4-4.1) and serum 25 (OH) vitamin D levels <30â¯ng/ml ORâ¯=â¯2.1, 95% CIâ¯=â¯1.8-2.5) were associated with PFAPA occurrence.CONCLUSION:
We found strong correlation between PFAPA and vitamin D insufficiency. Hypovitaminosis D can be a significant risk factor for PFAPA episode recurrence.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Doenças Hereditárias Autoinflamatórias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Ano de publicação:
2019
Tipo de documento:
Article