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IPT in people living with HIV in Myanmar: a five-fold decrease in incidence of TB disease and all-cause mortality.
Kyaw, N T T; Kumar, A M V; Kyaw, K W Y; Satyanarayana, S; Magee, M J; Min, A C; Moe, J; Aung, Z Z; Aung, T K; Oo, M M; Soe, K T; Oo, H N; Aung, S T; Harries, A D.
Afiliação
  • Kyaw NTT; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar, Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia, USA.
  • Kumar AMV; The Union, Paris, France.
  • Kyaw KWY; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar.
  • Satyanarayana S; The Union South-East Asia Office, New Delhi, India.
  • Magee MJ; Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia, USA.
  • Min AC; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar.
  • Moe J; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar.
  • Aung ZZ; National HIV/AIDS Programme, Department of Public Health, Naypyidaw, Myanmar.
  • Aung TK; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar.
  • Oo MM; International Union Against Tuberculosis and Lung Disease (The Union), Myanmar Office, Mandalay, Myanmar.
  • Soe KT; Department of Medical Research, Pyin Oo Lwin Branch.
  • Oo HN; National HIV/AIDS Programme, Department of Public Health, Naypyidaw, Myanmar.
  • Aung ST; National Tuberculosis Programme, Department of Public Health, Naypyidaw, Myanmar.
  • Harries AD; The Union, Paris, France, London School of Hygiene & Tropical Medicine, London, UK.
Int J Tuberc Lung Dis ; 23(3): 322-330, 2019 03 01.
Article em En | MEDLINE | ID: mdl-30871663
SETTING: Myanmar, a country with a high human immunodeficiency virus-tuberculosis (HIV-TB) burden, where the tuberculin skin test or interferon-gamma release assays are not routinely available for the diagnosis of latent tuberculous infection. OBJECTIVE: To assess the effect of isoniazid (INH) preventive therapy (IPT) on the risk of TB disease and mortality among people living with HIV (PLHIV). DESIGN: A retrospective cohort study of routinely collected data on PLHIV enrolled into care between 2009 and 2014. RESULTS: Of 7177 patients (median age 36 years, interquartile range 31-42; 53% male) included in the study, 1278 (18%) patients received IPT. Among patients receiving IPT, 855 (67%) completed 6 or 9 months of INH. Patients who completed IPT had a significantly lower risk of incident TB than those who never received IPT (adjusted hazard ratio [aHR] 0.21, 95%CI 0.12-0.34) after controlling for potential confounders. PLHIV who received IPT had a significantly lower risk of death than those who never received IPT (PLHIV who completed IPT, aHR 0.25, 95%CI 0.16-0.37; those who received but did not complete IPT, aHR 0.55, 95%CI 0.37-0.82). CONCLUSION: Among PLHIV in Myanmar, completing a course of IPT significantly reduced the risk of TB disease, and receiving IPT significantly reduced the risk of death.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Isoniazida / Antituberculosos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Isoniazida / Antituberculosos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Ano de publicação: 2019 Tipo de documento: Article