Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia.
Pediatr Blood Cancer
; 66(7): e27732, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30900813
ABSTRACT
Invasive fusariosis (IF) most commonly occurs in patients with hematologic malignancies and severe neutropenia, particularly during concomitant corticosteroid use. Breakthrough infections can occur in high-risk patients despite Aspergillus-active antifungal prophylaxis. We describe a patient with rapid acute lymphoblastic leukemia (ALL) progression who presented with multifocal skin nodules thought to be choloromatous disease. These lesions were ultimately diagnosed as IF and the patient had two simultaneously active disease processes. This case highlights the importance of pathologic diagnosis of new skin lesions in ALL patients, even during leukemia progression, and demonstrates that IF can occur despite normal neutrophil counts and Aspergillus-active prophylaxis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma Linfoblástico de Células Precursoras
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Fusariose
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Pediatr Blood Cancer
Ano de publicação:
2019
Tipo de documento:
Article