Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis.

Petpiroon, Nalinrat; Bhummaphan, Narumol; Tungsukruthai, Sucharat; Pinkhien, Tatchakorn; Maiuthed, Arnatchai; Sritularak, Boonchoo; Chanvorachote, Pithi

Petpiroon, Nalinrat; Bhummaphan, Narumol; Tungsukruthai, Sucharat; Pinkhien, Tatchakorn; Maiuthed, Arnatchai; Sritularak, Boonchoo; Chanvorachote, Pithi.

Afiliação

Petpiroon N; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Bhummaphan N; Interdisciplinary Program of Biomedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Tungsukruthai S; Interdisciplinary Program of Pharmacology Graduate School, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Pinkhien T; Pharmacuetical Technology (International) Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Maiuthed A; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Sritularak B; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Chanvorachote P; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: p

Phytomedicine ; 58: 152888, 2019 May.

Article em En | MEDLINE | ID: mdl-30901662

Assuntos

Antineoplásicos/farmacologia; Bibenzilas/farmacologia; Caveolina 1/metabolismo; Integrinas/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Antineoplásicos Fitogênicos/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/farmacologia; Regulação para Baixo/efeitos dos fármacos; Interações Medicamentosas; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Humanos; Neoplasias Pulmonares/patologia; Pseudópodes/efeitos dos fármacos

Palavras-chave

Caveolin-1; Chrysotobibenzyl; Integrin; Lung cancer; Metastasis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Bibenzilas / Integrinas / Caveolina 1 / Neoplasias Pulmonares / Antineoplásicos Limite: Humans Idioma: En Revista: Phytomedicine Ano de publicação: 2019 Tipo de documento: Article

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