Lung cancer and residential radon in never-smokers: A pooling study in the Northwest of Spain.
Environ Res
; 172: 713-718, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30903971
ABSTRACT
BACKGROUND:
Using a pooled case-control study design, including only never-smokers, we have assessed the association of residential radon exposure with the subsequent occurrence of lung cancer. We also investigated whether residential radon poses a different risk specifically for adenocarcinoma.METHODS:
We pooled individual data from different case-control studies conducted in recent years in Northwestern Spain which investigated residential radon and lung cancer. All participants were never-smokers. Cases had a confirmed biopsy of primary lung cancer. Hospital controls were selected at pre-surgery units, presenting for non-complex surgical procedures. They were interviewed using a standardized instrument. Residential radon was measured using alpha track detectors at the Galician Radon Laboratory at the University of Santiago de Compostela.RESULTS:
A total of 1415 individuals, 523 cases and 892 controls were included. We observed an odds ratio of 1.73 (95%CI 1.27-2.35) for individuals exposed to ≥â¯200â¯Bq/m3 compared with those exposed to ≤100â¯Bq/m3. Lung cancer risk for adenocarcinoma was 1.52 (95%CI 1.14-2.02) using the same categories for radon exposure.CONCLUSIONS:
Residential radon is a clear risk factor for lung cancer in never-smokers. Our data suggest that radon exposure is associated with all histological types of lung cancer and also with adenocarcinoma, which is currently the most frequent histological type for this disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Radônio
/
Poluição do Ar em Ambientes Fechados
/
Não Fumantes
/
Neoplasias Pulmonares
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2019
Tipo de documento:
Article