How cardiolipin modulates the dynamics of respiratory complex I.
Sci Adv
; 5(3): eaav1850, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30906865
ABSTRACT
Cardiolipin modulates the activity of membrane-bound respiratory enzymes that catalyze biological energy transduction. The respiratory complex I functions as the primary redox-driven proton pump in mitochondrial and bacterial respiratory chains, and its activity is strongly enhanced by cardiolipin. However, despite recent advances in the structural biology of complex I, cardiolipin-specific interaction mechanisms currently remain unknown. On the basis of millisecond molecular simulations, we suggest that cardiolipin binds to proton-pumping subunits of complex I and induces global conformational changes that modulate the accessibility of the quinone substrate to the enzyme. Our findings provide key information on the coupling between complex I dynamics and activity and suggest how biological membranes modulate the structure and activity of proteins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Cardiolipinas
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Subunidades Proteicas
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Complexo I de Transporte de Elétrons
Idioma:
En
Revista:
Sci Adv
Ano de publicação:
2019
Tipo de documento:
Article