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Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications.
Zoratto, Nicole; Palmieri, Francesca Romana; Cencetti, Claudia; Montanari, Elita; Di Meo, Chiara; Manca, Maria Letizia; Manconi, Maria; Matricardi, Pietro.
Afiliação
  • Zoratto N; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. nicole.zoratto@uniroma1.it.
  • Palmieri FR; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. palmieri.1247758@studenti.uniroma1.it.
  • Cencetti C; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. claudia.cencetti@gmail.com.
  • Montanari E; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. elita.montanari@uniroma1.it.
  • Di Meo C; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. chiara.dimeo@uniroma1.it.
  • Manca ML; Department of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy. mlmanca@unica.it.
  • Manconi M; Department of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy. manconi@unica.it.
  • Matricardi P; Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy. pietro.matricardi@uniroma1.it.
Gels ; 3(2)2017 May 08.
Article em En | MEDLINE | ID: mdl-30920514
ABSTRACT
Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug depot applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Gels Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Gels Ano de publicação: 2017 Tipo de documento: Article