Fine-tuning of the automated [18 F]PSMA-1007 radiosynthesis.
J Labelled Comp Radiopharm
; 62(6): 252-258, 2019 05 30.
Article
em En
| MEDLINE
| ID: mdl-30941793
ABSTRACT
Radiolabeled prostate-specific membrane antigen (PSMA) targeting PET-tracers have become desirable radiopharmaceuticals for the imaging of prostate cancer (PC). Recently, the PET radiotracer [18 F]PSMA-1007 was introduced as an alternative to [68 Ga]Ga-PSMA-11, for staging and diagnosing biochemically recurrent PC. We incorporated a one-step procedure for [18 F]PSMA-1007 radiosynthesis, using both Synthra RNplus and GE TRACERlab FxFN automated modules, in accordance with the recently described radiolabeling procedure. Although the adapted [18 F]PSMA-1007 synthesis resulted in repeatable radiochemical yields (55 ± 5%, NDC), suboptimal radiochemical purities of 87 ± 8% were obtained using both modules. As described here, modifications made to the radiolabeling and the solid-phase extraction purification steps reduced synthesis time to 32 minutes and improved radiochemical purity to 96.10%, using both modules, without shearing the radiochemical yield.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Radioquímica
/
Radioisótopos de Flúor
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Niacinamida
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2019
Tipo de documento:
Article