Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair.

Kim, Hee Jung; Han, Min Ah; Shin, Ji Young; Jeon, Jeong Hwa; Lee, Seung Jin; Yoon, Mi Yun; Kim, Han-Jun; Choi, Eun-Ji; Do, Sun Hee; Yang, Victor C; He, Huining; Yang, Young-Il

Kim, Hee Jung; Han, Min Ah; Shin, Ji Young; Jeon, Jeong Hwa; Lee, Seung Jin; Yoon, Mi Yun; Kim, Han-Jun; Choi, Eun-Ji; Do, Sun Hee; Yang, Victor C; He, Huining; Yang, Young-Il.

Afiliação

Kim HJ; Department of Pharmacy, College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
Han MA; Department of Pharmacy, College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
Shin JY; Department of Pharmacy, College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
Jeon JH; Department of Pharmacy, College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
Lee SJ; Department of Pharmacy, College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. Electronic address: sjlee@ewha.ac.kr.
Yoon MY; Department of cosmetology, Dongnam Health University, 50, cheoncheon-ro 74-gil, Jangan-gu, Suwon-si, Gyeonggi-do 16328, Republic of Korea.
Kim HJ; Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Choi EJ; Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Do SH; Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address: shdo@konkuk.ac.kr.
Yang VC; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
He H; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Yang YI; Paik Institute for Clinical Research, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea. Electronic address: pathyang@inje.ac.kr.

J Control Release ; 302: 169-180, 2019 05 28.

Article em En | MEDLINE | ID: mdl-30954618

Assuntos

Proteína Morfogenética Óssea 7/química; Cartilagem Articular/efeitos dos fármacos; Portadores de Fármacos/química; Células-Tronco Mesenquimais/metabolismo; Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química; Membrana Sinovial/química; Animais; Medula Óssea/metabolismo; Proteína Morfogenética Óssea 7/farmacocinética; Regeneração Óssea/efeitos dos fármacos; Condrogênese/efeitos dos fármacos; Colágeno Tipo II/metabolismo; Liberação Controlada de Fármacos; Fibrina/química; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Injeções Intra-Articulares; Masculino; Transplante de Células-Tronco Mesenquimais; Osteogênese/efeitos dos fármacos; Proteoglicanas/metabolismo; Coelhos; Engenharia Tecidual; Alicerces Teciduais/química

Palavras-chave

Articular cartilage repair; Bone morphogenetic protein-7; Combined delivery; PLGA fibrous scaffold; Synovium-resident mesenchymal stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Sinovial / Portadores de Fármacos / Cartilagem Articular / Proteína Morfogenética Óssea 7 / Células-Tronco Mesenquimais / Copolímero de Ácido Poliláctico e Ácido Poliglicólico Limite: Animals / Humans / Male Idioma: En Revista: J Control Release Ano de publicação: 2019 Tipo de documento: Article

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