microRNA-30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK/STAT signaling pathway by targeting SOCS-1 in rats with sepsis.

Yuan, Feng-Hua; Chen, You-Lian; Zhao, Ying; Liu, Zhen-Mi; Nan, Chuan-Chuan; Zheng, Biao-Lin; Liu, Xue-Yan; Chen, Xiao-Yin

Yuan, Feng-Hua; Chen, You-Lian; Zhao, Ying; Liu, Zhen-Mi; Nan, Chuan-Chuan; Zheng, Biao-Lin; Liu, Xue-Yan; Chen, Xiao-Yin.

Afiliação

Yuan FH; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Chen YL; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Shenzhen, People's Republic of China.
Zhao Y; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Liu ZM; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Nan CC; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Zheng BL; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Liu XY; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.
Chen XY; Department of Critical Care Medicine, The Second Clinical Medicine College, Shenzhen People's Hospital, Jinan University, Shenzhen, People's Republic of China.

J Cell Physiol ; 234(10): 17839-17853, 2019 08.

Article em En | MEDLINE | ID: mdl-30972748

Assuntos

Apoptose/genética; Proliferação de Células/genética; Janus Quinase 2/genética; MicroRNAs/genética; Fator de Transcrição STAT3/genética; Sepse/genética; Proteína 1 Supressora da Sinalização de Citocina/genética; Animais; Regulação para Baixo/genética; Hepatócitos/fisiologia; Fígado/fisiologia; Masculino; Fosforilação/genética; Ratos; Ratos Wistar; Transdução de Sinais/genética; Regulação para Cima/genética

Palavras-chave

JAK/STAT signaling pathway; microRNA-30a (miR-30a); sepsis; suppressor of cytokine signaling protein 1 (SOCS-1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Sepse / MicroRNAs / Proliferação de Células / Fator de Transcrição STAT3 / Janus Quinase 2 / Proteína 1 Supressora da Sinalização de Citocina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Cell Physiol Ano de publicação: 2019 Tipo de documento: Article

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