Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats.

Matthes, Susann; Mosienko, Valentina; Popova, Elena; Rivalan, Marion; Bader, Michael; Alenina, Natalia

Matthes, Susann; Mosienko, Valentina; Popova, Elena; Rivalan, Marion; Bader, Michael; Alenina, Natalia.

Afiliação

Matthes S; Max-Delbrück Center for Molecular Medicine (MDC) , Robert-Rössle-Straße 10 , 13125 Berlin-Buch , Germany.
Mosienko V; Institute for Biology , University of Lübeck , Ratzeburger Allee 160 , 23562 Lübeck , Germany.
Popova E; Max-Delbrück Center for Molecular Medicine (MDC) , Robert-Rössle-Straße 10 , 13125 Berlin-Buch , Germany.
Rivalan M; College of Medicine and Health, Institute of Biomedical and Clinical Sciences , University of Exeter , Hatherly Building, Prince of Wales Rd. , EX4 4PS Exeter , United Kingdom.
Bader M; Max-Delbrück Center for Molecular Medicine (MDC) , Robert-Rössle-Straße 10 , 13125 Berlin-Buch , Germany.
Alenina N; Charité University Medicine , Charitéplatz 1 , 10117 Berlin , Germany.

ACS Chem Neurosci ; 10(7): 3207-3217, 2019 07 17.

Article em En | MEDLINE | ID: mdl-30977636

Assuntos

Neurônios/metabolismo; Núcleos da Rafe/metabolismo; Serotonina/metabolismo; Triptofano Hidroxilase/metabolismo; Animais; Córtex Cerebral/metabolismo; Técnicas de Silenciamento de Genes; Hipocampo/metabolismo; Ácido Hidroxi-Indolacético/metabolismo; Hipotálamo/metabolismo; Interferência de RNA; Ratos; Ratos Transgênicos; Triptofano Hidroxilase/genética

Palavras-chave

RNA interference; Serotonin; depression; transgenic rat; tryptophan hydroxylase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano Hidroxilase / Núcleos da Rafe / Serotonina / Neurônios Limite: Animals Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2019 Tipo de documento: Article

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