M1 Muscarinic Receptor Activation Rescues ß-Amyloid-Induced Cognitive Impairment through AMPA Receptor GluA1 Subunit.

Zhao, Lan-Xue; Chen, Mu-Wen; Qian, Yue; Yang, Qian-Hao; Ge, Yan-Hui; Chen, Hong-Zhuan; Qiu, Yu

Zhao, Lan-Xue; Chen, Mu-Wen; Qian, Yue; Yang, Qian-Hao; Ge, Yan-Hui; Chen, Hong-Zhuan; Qiu, Yu.

Afiliação

Zhao LX; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chen MW; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Qian Y; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yang QH; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ge YH; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chen HZ; Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. Electronic address: yaoli@shsmu.edu.cn.
Qiu Y; Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: qiuy@shsmu.edu.cn.

Neuroscience ; 408: 239-247, 2019 06 01.

Article em En | MEDLINE | ID: mdl-30981860

Assuntos

Peptídeos beta-Amiloides/farmacologia; Disfunção Cognitiva/tratamento farmacológico; Agonistas Muscarínicos/farmacologia; Fragmentos de Peptídeos/farmacologia; Receptores de AMPA/metabolismo; Aprendizagem Espacial/efeitos dos fármacos; Memória Espacial/efeitos dos fármacos; Animais; Disfunção Cognitiva/induzido quimicamente; Disfunção Cognitiva/metabolismo; Modelos Animais de Doenças; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Camundongos; Agonistas Muscarínicos/uso terapêutico; Fosforilação; Receptor Muscarínico M1/metabolismo

Palavras-chave

Alzheimer's disease; spatial learning and memory; synaptic incorporation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Receptores de AMPA / Agonistas Muscarínicos / Disfunção Cognitiva / Aprendizagem Espacial / Memória Espacial Limite: Animals Idioma: En Revista: Neuroscience Ano de publicação: 2019 Tipo de documento: Article

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