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Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study.
Degirmenci, Erdem; Ozturan, Kutay Engin; Sahin, Abdullah Alper; Yilmaz, Fahri; Kaya, Yasin Emre.
Afiliação
  • Degirmenci E; Faculty of Medicine, Department of Orthopaedic and Traumatology, Duzce University, Duzce, Turkey. erddegir@gmail.com.
  • Ozturan KE; Faculty of Medicine, Department of Orthopaedic and Traumatology, Abant Izzet Baysal University, Bolu, Turkey.
  • Sahin AA; Department of Orthopaedic and Traumatology, Tokat Turhal State Hospital, Tokat, Turkey.
  • Yilmaz F; Faculty of Medicine, Department of Pathology, Sakarya University, Sakarya, Turkey.
  • Kaya YE; Faculty of Medicine, Department of Orthopaedic and Traumatology, Abant Izzet Baysal University, Bolu, Turkey.
J Orthop Surg Res ; 14(1): 105, 2019 Apr 15.
Article em En | MEDLINE | ID: mdl-30992060
BACKGROUND: Microfracture and scaffold application in the treatment of osteochondral defects is still one of the most frequently used methods in the clinic. The most important step in this treatment method is the stabilization of fibrin clot. Tranexamic acid (TA) is an antifibrinolytic agent commonly used in orthopedic surgery in recent years. This study evaluated the effect of local TA application on healing of experimentally induced osteochondral defects on rabbits. METHODS: This paper contains an animal in vivo data and histological outcomes on the effect of TA. Eighteen New Zealand white rabbits were treated unilaterally and cylindrical defects having a width of 4 mm and depth of 5 mm were created in the weight-bearing surfaces of the medial and lateral condyles of the right femur. They were divided into two groups, as group 1 study and group 2 control groups, respectively. One milliliter (ml) of TA was injected into the knee joints of the subjects in group 1. All animals were sacrificed for the extraction of the femur condyles for histologic study at the fourth and eighth weeks after surgery. Histological evaluations were performed by Brittberg and O'Driscoll scores to all samples. Data were organized in a Standard Statistical Package System v.22 software package (SPSS/PC Inc., Chicago, IL.) and reported as mean and median (min-max). Repeated measures ANOVA test was used to compare groups and condyle effects together for each week. p values below 0.05 were considered as statistically significant. RESULTS: Samples were taken in the fourth and eighth weeks. The regularity of the surface in group 1 was smoother, and the tissue stability was more robust. Mean Brittberg scores in both weeks were statistically higher in group 1 when compared with group 2. In the microscopic evaluation, it was observed that the regeneration of subchondral and cartilage tissues were more rapid and organized in group 1, and the mean O' Driscoll scores in both weeks were statistically higher in group 1. CONCLUSIONS: Application of TA improves the healing time and tissue stability in osteochondral defects which are implanted a-cellular scaffold after microfracture and should be applicable to humans for the treatment of osteochondral defects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Tranexâmico / Fraturas de Estresse / Recuperação de Função Fisiológica / Alicerces Teciduais / Fêmur / Antifibrinolíticos Limite: Animals Idioma: En Revista: J Orthop Surg Res Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Tranexâmico / Fraturas de Estresse / Recuperação de Função Fisiológica / Alicerces Teciduais / Fêmur / Antifibrinolíticos Limite: Animals Idioma: En Revista: J Orthop Surg Res Ano de publicação: 2019 Tipo de documento: Article