The Role of RP105 in Cardiovascular Disease through Regulating TLR4 and PI3K Signaling Pathways.
Curr Med Sci
; 39(2): 185-189, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-31016532
ABSTRACT
Raidoprotective 105 (RP105) was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease (CVD), such as myocardial ischemic reperfusion injury (MI/RI), atherosclerosis and myocardial infarction (MI). As a member of Toll-like receptor (TLR) homolog which is capable of regulating toll-like receptor (TLR4) signaling pathway, RP105 is implicated in various biological processes. Mounting evidence suggests that RP105 regulates the function of TLR4 and phosphoinositide 3-kinase (PI3K) signaling pathways. Here, we review the effect of RP105 on CVD through regulating TLR4/PI3K signaling pathways.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Transdução de Sinais
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Antígenos CD
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Fosfatidilinositol 3-Quinases
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Receptor 4 Toll-Like
Limite:
Animals
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Humans
Idioma:
En
Revista:
Curr Med Sci
Ano de publicação:
2019
Tipo de documento:
Article