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In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
Zhang, Jiang Wei; Deng, Hai Bing; Zhang, Chun Ye; Dai, Jing Quan; Li, Qian; Zheng, Qian Gang; Wan, Hui Xin; Yu, Hong Ping; He, Feng; Xu, Yao Chang; Zhao, Sylvia; Zhang, Ji Yue Jeff.
Afiliação
  • Zhang JW; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China. zjw@dicp.ac.cn.
  • Deng HB; InxMed, Shanghai, China. zjw@dicp.ac.cn.
  • Zhang CY; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China.
  • Dai JQ; Abbisko Therapeutics, Shanghai, China.
  • Li Q; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China.
  • Zheng QG; Luoxin Biotechnology, Shanghai, China.
  • Wan HX; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China.
  • Yu HP; Tayu Biotech, Beijing, China.
  • He F; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China.
  • Xu YC; Janssen (China) R&D Center, Shanghai, China.
  • Zhao S; Novartis Institutes for BioMedical Research, B4F2 Novartis Campus, No. 4218 Jinke Road, Shanghai, 201203, China.
  • Zhang JYJ; EternBio, Shanghai, China.
Eur J Drug Metab Pharmacokinet ; 44(5): 669-680, 2019 Oct.
Article em En | MEDLINE | ID: mdl-31030415
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-met / Aldeído Oxidase / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Eur J Drug Metab Pharmacokinet Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-met / Aldeído Oxidase / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Eur J Drug Metab Pharmacokinet Ano de publicação: 2019 Tipo de documento: Article