Simultaneous determination of tenofovir alafenamide and tenofovir in human plasma by LC-MS/MS and its application to pharmacokinetics study in clinic.

Zhao, Lizhi; Li, Zhou; Zhou, Zhen; Kang, Xiuyuan; Fang, Baihuan; Ma, Huan; Ge, Qinghua

Zhao, Lizhi; Li, Zhou; Zhou, Zhen; Kang, Xiuyuan; Fang, Baihuan; Ma, Huan; Ge, Qinghua.

Afiliação

Zhao L; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.
Li Z; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China. Electronic address: lizhou@nperc.com.
Zhou Z; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.
Kang X; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.
Fang B; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.
Ma H; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.
Ge Q; Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering and Research Center, 1111 Halei Road, Zhangjiang Hi-Tech Park, Shanghai, China.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1117: 148-157, 2019 Jun 01.

Article em En | MEDLINE | ID: mdl-31031221

Assuntos

Adenina/análogos & derivados; Cromatografia Líquida/métodos; Espectrometria de Massas em Tandem/métodos; Tenofovir/sangue; Adenina/sangue; Adenina/química; Adenina/farmacocinética; Adolescente; Adulto; Alanina; Feminino; Humanos; Limite de Detecção; Modelos Lineares; Masculino; Pessoa de Meia-Idade; Reprodutibilidade dos Testes; Tenofovir/química; Tenofovir/farmacocinética; Adulto Jovem

Palavras-chave

LC-MS/MS; Pharmacokinetic; Simultaneous determination; Stability; Tenofovir; Tenofovir alafenaminde

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenina / Cromatografia Líquida / Espectrometria de Massas em Tandem / Tenofovir Tipo de estudo: Guideline / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Ano de publicação: 2019 Tipo de documento: Article

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