Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy.

Parvatiyar, Michelle S; Brownstein, Alexandra J; Kanashiro-Takeuchi, Rosemeire M; Collado, Judd R; Dieseldorff Jones, Karissa M; Gopal, Jay; Hammond, Katherine G; Marshall, Jamie L; Ferrel, Abel; Beedle, Aaron M; Chamberlain, Jeffrey S; Renato Pinto, Jose; Crosbie, Rachelle H

Parvatiyar, Michelle S; Brownstein, Alexandra J; Kanashiro-Takeuchi, Rosemeire M; Collado, Judd R; Dieseldorff Jones, Karissa M; Gopal, Jay; Hammond, Katherine G; Marshall, Jamie L; Ferrel, Abel; Beedle, Aaron M; Chamberlain, Jeffrey S; Renato Pinto, Jose; Crosbie, Rachelle H.

Afiliação

Parvatiyar MS; Department of Integrative Biology & Physiology and.
Brownstein AJ; Center for Duchenne Muscular Dystrophy, UCLA, Los Angeles, California, USA.
Kanashiro-Takeuchi RM; Department of Integrative Biology & Physiology and.
Collado JR; Center for Duchenne Muscular Dystrophy, UCLA, Los Angeles, California, USA.
Dieseldorff Jones KM; Interdisciplinary Stem Cell Institute, University of Miami, Florida, USA.
Gopal J; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Hammond KG; Department of Integrative Biology & Physiology and.
Marshall JL; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Ferrel A; Department of Integrative Biology & Physiology and.
Beedle AM; Department of Integrative Biology & Physiology and.
Chamberlain JS; Center for Duchenne Muscular Dystrophy, UCLA, Los Angeles, California, USA.
Renato Pinto J; Department of Integrative Biology & Physiology and.
Crosbie RH; Center for Duchenne Muscular Dystrophy, UCLA, Los Angeles, California, USA.

JCI Insight ; 52019 04 30.

Article em En | MEDLINE | ID: mdl-31039133

Assuntos

Cardiomiopatias/terapia; Terapia Genética/métodos; Proteínas de Membrana/genética; Distrofia Muscular de Duchenne/complicações; Proteínas de Neoplasias/genética; Sarcolema/patologia; Animais; Cardiomiopatias/diagnóstico; Cardiomiopatias/etiologia; Modelos Animais de Doenças; Distrofina/genética; Ecocardiografia; Feminino; Humanos; Integrina beta1; Masculino; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos mdx; Camundongos Transgênicos; Contração Muscular/genética; Músculo Esquelético/citologia; Músculo Esquelético/patologia; Distrofia Muscular de Duchenne/genética; Distrofia Muscular de Duchenne/terapia; Miocárdio/citologia; Miocárdio/patologia; Proteínas de Neoplasias/metabolismo; Estabilidade Proteica; Utrofina/metabolismo

Palavras-chave

Cardiology; Fibrosis; Gene therapy; Muscle Biology; Skeletal muscle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcolema / Terapia Genética / Distrofia Muscular de Duchenne / Proteínas de Membrana / Cardiomiopatias / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: JCI Insight Ano de publicação: 2019 Tipo de documento: Article

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