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Idiosyncrasies of Viral Noncoding RNAs Provide Insights into Host Cell Biology.
Withers, Johanna B; Mondol, Vanessa; Pawlica, Paulina; Rosa-Mercado, Nicolle A; Tycowski, Kazimierz T; Ghasempur, Salehe; Torabi, Seyed F; Steitz, Joan A.
Afiliação
  • Withers JB; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
  • Mondol V; Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
  • Pawlica P; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
  • Rosa-Mercado NA; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
  • Tycowski KT; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
  • Ghasempur S; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
  • Torabi SF; Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
  • Steitz JA; Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA; email: johanna.withers@yale.edu, vanessa.mondol@yale.edu, paulina.pawlica@yale.edu, nicolle.rosa-mercado@yale.edu, ktt@yale.edu, salehe.gha
Annu Rev Virol ; 6(1): 297-317, 2019 09 29.
Article em En | MEDLINE | ID: mdl-31039329
Like their host cells, many viruses express noncoding RNAs (ncRNAs). Despite the technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been described, including regulation of viral replication, modulation of host gene expression, host immune evasion, cellular survival, and cellular transformation. Insights into conserved interactions between viral ncRNAs and host cell machinery frequently lead to novel findings concerning host cell biology. In this review, we discuss the functions and biogenesis of ncRNAs produced by animal viruses. Specifically, we describe noncanonical pathways of microRNA (miRNA) biogenesis and novel mechanisms used by viruses to manipulate miRNA and messenger RNA stability. We also highlight recent advances in understanding the function of viral long ncRNAs and circular RNAs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / RNA Viral / Regulação Viral da Expressão Gênica / RNA não Traduzido / Interações entre Hospedeiro e Microrganismos Limite: Animals Idioma: En Revista: Annu Rev Virol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / RNA Viral / Regulação Viral da Expressão Gênica / RNA não Traduzido / Interações entre Hospedeiro e Microrganismos Limite: Animals Idioma: En Revista: Annu Rev Virol Ano de publicação: 2019 Tipo de documento: Article