The base-free van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro ß-carboline derivatives.
Org Biomol Chem
; 17(21): 5234-5238, 2019 05 29.
Article
em En
| MEDLINE
| ID: mdl-31074750
ABSTRACT
Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro ß-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro ß-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2019
Tipo de documento:
Article