Microchannels in Development, Survival, and Vascularisation of Tissue Analogues for Regenerative Medicine.
Trends Biotechnol
; 37(11): 1189-1201, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31076248
ABSTRACT
Microchannels are simple, perfusable architectural features engineered into biomaterials to promote mass transport of solutes to cells, effective cell seeding and compartmentalisation for tissue engineering applications, control over spatiotemporal distribution of molecules and ligands, and survival, integration, and vascularisation of engineered tissue analogues in vivo. Advances in biofabrication have led to better control over microchannel fabrication in 3D scaffolds, enabling sophisticated designs that drive the development of complex tissue structures. This review addresses the importance of microchannel structures in biomaterial design and regenerative medicine, and discusses their function, fabrication methods, and proposed mechanisms underlying their effects.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Medicina Regenerativa
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
2019
Tipo de documento:
Article