Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist <sup>177</sup> Lu-DOTAGA-PEG<sub>2</sub> -RM26.

Mitran, Bogdan; Rinne, Sara S; Konijnenberg, Mark W; Maina, Theodosia; Nock, Berthold A; Altai, Mohamed; Vorobyeva, Anzhelika; Larhed, Mats; Tolmachev, Vladimir; de Jong, Marion; Rosenström, Ulrika; Orlova, Anna

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist ¹⁷⁷ Lu-DOTAGA-PEG₂ -RM26.

Mitran, Bogdan; Rinne, Sara S; Konijnenberg, Mark W; Maina, Theodosia; Nock, Berthold A; Altai, Mohamed; Vorobyeva, Anzhelika; Larhed, Mats; Tolmachev, Vladimir; de Jong, Marion; Rosenström, Ulrika; Orlova, Anna.

Afiliação

Mitran B; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Rinne SS; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Konijnenberg MW; Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Maina T; Molecular Radiopharmacy, INRASTES, NCSR "Demokritos", Athens, Greece.
Nock BA; Molecular Radiopharmacy, INRASTES, NCSR "Demokritos", Athens, Greece.
Altai M; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Vorobyeva A; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Larhed M; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Tolmachev V; Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
de Jong M; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Rosenström U; Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Orlova A; Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Int J Cancer ; 145(12): 3347-3358, 2019 12 15.

Article em En | MEDLINE | ID: mdl-31077356

Assuntos

Antineoplásicos/farmacologia; Lutécio/química; Polietilenoglicóis/química; Neoplasias da Próstata/tratamento farmacológico; Radioisótopos/química; Receptores da Bombesina/antagonistas & inibidores; Trastuzumab/farmacologia; Animais; Antineoplásicos/química; Linhagem Celular Tumoral; Terapia Combinada/métodos; Xenoenxertos/efeitos dos fármacos; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Células PC-3; Próstata/efeitos dos fármacos; Distribuição Tecidual/fisiologia; Proteína Tumoral 1 Controlada por Tradução

Palavras-chave

GRPR; HER2; lutetium-177; prostate cancer; radionuclide therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Neoplasias da Próstata / Radioisótopos / Receptores da Bombesina / Trastuzumab / Lutécio / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Int J Cancer Ano de publicação: 2019 Tipo de documento: Article

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