The target therapeutic effect of functionalized graphene oxide nanoparticles graphene oxide-polyethylene glycol-folic acid-1-pyrenemethylamine hydrochloride-mediated RNA interference of HIF-1&#945; gene in human pancreatic cancer cells.

Wan, Renming; Luan, Yufen; Wu, Zhouquan; Deng, Shengming; Peng, Mingya; Xu, Longbao; Wu, Yiwei; Qin, Xihu; Fan, Guanglei

The target therapeutic effect of functionalized graphene oxide nanoparticles graphene oxide-polyethylene glycol-folic acid-1-pyrenemethylamine hydrochloride-mediated RNA interference of HIF-1α gene in human pancreatic cancer cells.

Wan, Renming; Luan, Yufen; Wu, Zhouquan; Deng, Shengming; Peng, Mingya; Xu, Longbao; Wu, Yiwei; Qin, Xihu; Fan, Guanglei.

Afiliação

Wan R; 1 Department of Clinical Laboratory, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.
Luan Y; 2 Department of Nuclear Medicine, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.
Wu Z; 3 Department of Anesthesia, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Deng S; 4 Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Peng M; 2 Department of Nuclear Medicine, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.
Xu L; 2 Department of Nuclear Medicine, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.
Wu Y; 4 Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qin X; 5 Department of General Surgery, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.
Fan G; 2 Department of Nuclear Medicine, Changzhou Second People's Hospital, Nanjing Medical University, Changzhou, China.

J Biomater Appl ; 34(2): 155-177, 2019 08.

Article em En | MEDLINE | ID: mdl-31079557

Assuntos

Ácido Fólico/química; Grafite/química; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Metilaminas/química; Nanopartículas/química; Neoplasias Pancreáticas/terapia; Polietilenoglicóis/química; Pirenos/química; Animais; Linhagem Celular Tumoral; Portadores de Fármacos/química; Portadores de Fármacos/metabolismo; Fluordesoxiglucose F18/metabolismo; Técnicas de Silenciamento de Genes; Terapia Genética; Transportador de Glucose Tipo 1/genética; Transportador de Glucose Tipo 1/metabolismo; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Camundongos Nus; Terapia de Alvo Molecular; Nanopartículas/metabolismo; Neoplasias Experimentais; Interferência de RNA/efeitos dos fármacos; RNA Mensageiro/efeitos dos fármacos; Transfecção

Palavras-chave

Hypoxia-inducible factor 1-alpha; RNA interference; deoxyglucose; functionalized graphene oxide; pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Polietilenoglicóis / Pirenos / Subunidade alfa do Fator 1 Induzível por Hipóxia / Nanopartículas / Ácido Fólico / Grafite / Metilaminas Limite: Animals / Humans Idioma: En Revista: J Biomater Appl Ano de publicação: 2019 Tipo de documento: Article

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