CDC20 associated with cancer metastasis and novel mushroomderived CDC20 inhibitors with antimetastatic activity.
Int J Oncol
; 54(6): 2250-2256, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31081056
ABSTRACT
Aberrant expression of cell division cycle 20 (CDC20) is associated with malignant progression and poor prognosis in various types of cancer. The development of specific CDC20 inhibitors may be a novel strategy for the treatment of cancer with elevated expression of CDC20. The aim of the current study was to elucidate the role of CDC20 in cancer cell invasiveness and to identify novel natural inhibitors of CDC20. The authors found that CDC20 knockdown inhibited the migration of chemoresistant PANC1 pancreatic cancer cells and the metastatic MDAMB231 breast cancer cell line. By contrast, the overexpression of CDC20 by plasmid transfection promoted the metastasizing capacities of the PANC1 cells and MCF7 breast cancer cells. It was also identified that a triterpene mixture extracted from the mushroom Poria cocos (PTE), purified triterpenes dehydropachymic acid, and polyporenic acid C (PPAC) downregulated the expression of CDC20 in PANC1 cells dosedependently. Migration was also suppressed by PTE and PPAC in a dosedependent manner, which was consistent with expectations. Taken together, the present study is the first, to the best of our knowledge, to demonstrate that CDC20 serves an important role in cancer metastasis and that triterpenes from P. cocos inhibit the migration of pancreatic cancer cells associated with CDC20. Further investigations are in progress to investigate the specific mechanism associated with CDC20 and these triterpenes, which may have future potential use as natural agents in the treatment of metastatic cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Triterpenos
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Neoplasias da Mama
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Agaricales
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Proteínas Cdc20
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Metástase Neoplásica
Tipo de estudo:
Risk_factors_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Int J Oncol
Ano de publicação:
2019
Tipo de documento:
Article